Whenever I get to the portion of a design where I start setting the attributes for the copy, I'm always fiddling around with the font type, font sizes and line height. Well... as much as you can via CSS anyway.
Somehow I always end up with either 12px/16px or 14px/18px. Last night while going through another round of fiddling, I decided to see what the experts had to say about the line-height property and stumbled upon an easy 'set it and forget it' property. Just set the line-height to 140% for sans-serif fonts and 145% for serif fonts. So easy, even a caveman can do it. Thanks Charlie, your biggest fan.